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The substance is a 2024 body horror film written and directed by coralie fargeat In the latest episode of the envelope video podcast, director coralie fargeat explains how she prepared star demi moore to film the substance and the brutalist filmmaker brady corbet. Starring demi moore, margaret qualley, and dennis quaid, the film follows elisabeth sparkle (moore), a fading celebrity who, after being fired by her producer (quaid) due to her age, uses a black market drug that creates a younger version of herself (qualley) with unexpected side effects

The film is noted for. Demi moore revealed there were 'a lot of conversations' around the nude scenes in the substance. Demi moore opened up about her full frontal nude scene in the substance, an indie film that debuted at the cannes film festival.

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