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Over the past 35 years, the term leaky vaccine has gained widespread use in both mathematical modeling and epidemiologic methods for evaluating vaccines Leaky vaccines therefore protect subjects with fewer exposures at a higher effective rate than subjects with more exposures. Here, we present a short history, as we recall it, of how the term was coined in the context of the history of sporozoite malaria vaccines that were thought in the 1980s to be possibly.

These downstream effects of leaky vaccines on disease development and spread are currently poorly understood As the pathogen passes between vaccinated hosts, it can gain virulence without killing them — with severe consequences for any. They allow the spread of deadlier pathogens that would normally burn out quickly

Leaky vaccines are common for animal infections, including marek's disease.

Center for infectious disease dynamics cidd embraces all scales and components of infectious disease biology Our interdisciplinary approach, coupled with a dynamic viewpoint, provides insight into how to prevent or reduce infections. A leaky vaccine removes this pressure to become less virulent

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